Pharmacokinetic Effect of Ketoconazole on Solifenacin in Healthy Volunteers
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چکیده
منابع مشابه
Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers
OBJECTIVES Two open-label, two-period, crossover studies in healthy volunteers were designed to determine the pharmacokinetic interactions between ticagrelor, a P2Y12 receptor antagonist, and a moderate (diltiazem) and a strong (ketoconazole) cytochrome P450 (CYP) 3A inhibitor. METHODS Seventeen volunteers received diltiazem (240 mg once daily) for 14 days. In the second study, ketoconazole (...
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In this study, the pharmacokinetic parameters of two marketed tablet formulations of ketoconazole were studied, and the relative bioavailability of the test formulation was compared with a reference formulation. A single dose (12x2) double blind randomized cross-over study of a generic formulation of ketoconazole tablet (2x200 mg), and a commercial brand, Nizoral tablet (2x200 mg, Janssen...
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The pharmacokinetics of the antiepileptic agent lamotrigine (CAS 84057-84-1) was investigated after single oral doses in 14 healthy volunteers. After the administration of single oral doses of 2x100 mg lamotrigine chewable/soluble tablets to healthy volunteers, blood samples were collected for the next 96 h. The pharmacokinetic modelling of lamotrigine showed that the drug exhibited two compart...
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OBJECTIVES Latent tuberculosis infection and tuberculosis disease are prevalent worldwide. However, antimycobacterial rifamycins have drug interactions with many antiretroviral drugs. We evaluated the effect of rifapentine on the pharmacokinetic properties of raltegravir. METHODS In this open-label, fixed-sequence, three-period study, 21 healthy volunteers were given: raltegravir alone (400 m...
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ژورنال
عنوان ژورنال: Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology
سال: 2006
ISSN: 1742-7835,1742-7843
DOI: 10.1111/j.1742-7843.2006.pto_285.x